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tcyC [2017-08-16 12:36:09]
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tcyC [2017-08-16 12:36:09]

cystine ABC transporter, ATP-binding protein
locus
BSU03590
pI
7.19
mw
27.64 kDa
protein length
247 aa Sequence Blast
gene length
741 bp Sequence Blast
function
cystine uptake
product
cystine ABC transporter, ATP-binding protein
essential
no
synonyms
yckI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    409,208 → 409,951

    The protein

    Protein family

  • ABC transporter domain (according to Swiss-Prot)

    • Structure

  • [PDB|2Q0H] (in complex with ADP-Mg2+, Geobacillus stearothermophilus, 55% identity)

    • [SW|Localization]

  • attached to the membrane via [protein|9400DF25487461E3738DDDC72BDDB1589281409D|TcyB] [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]-[gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]-[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]
    description
    [Pubmed|22383849,15262924]

    regulation

  • strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]
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    Biological materials

    Mutant

  • MGNA-C004 (yckI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2002 NBRP B. subtilis, Japan]

    • References

  • 15262924,10092453,7551042